Nanoscribe GmbH - True 3D Laser Lithography
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3D Scaffolds and Biomimetics

Shown below is a series of structures fabricated by means of the direct laser writing technique with Photonic Professional systems. Typical topics of interest which are under investigation are the study of cell migration or stem cell differentiation. The 3D tailored environment acts as an artificial extracellular matrix, i.e., a scaffold for the cells. Pictures: F. Klein, B. Richter J. Fischer, T. Striebel und M. Bastmeyer; Karlsruher Institut für Technologie (KIT). Please click on the thumbnails to open a detailled view. Other applications are the fabrication of micro-needles, stents and so on for medical purposes.

SEM images of 3D polymer scaffold by direct laser writing.
Composite structure as a scaffold for cells.
Higher magnification image of an Ormocomp cube.
This polymer buckyball was 3D microprinted with a Photonic Professional system and can be used to trap cells inside.
Primary chicken fibroblasts adhering to one, two, or three protein-binding Ormocomp cubes.
Top view of the previous laser scanning microscope image.
3D reconstruction showing a single cell adhering to Ormocomp cubes in different heights.
SEM image of cell scaffold
3D reconstruction of LSM confocal image stack.
3D reconstruction of LSM confocal image stack (top view).
SEM image of cell scaffold made of ormocere.
3D reconstruction of LSM confocal image stack.
3D reconstruction of LSM confocal image stack (top view).
Labelled cardiomyocytes spanning a three-dimensional micro-environment.
3D reconstruction of LSM confocal image stack.
3D reconstruction of LSM confocal image stack.
Micro-scaffold / comb for cells.
Micro-needles.
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