Cell Scaffolds

Additive manufacturing by Photonic Professional GT2 systems enables the fabrication of designer 3D cell scaffolds and hence access to pioneering findings based on an analytical understanding of the cells’ interaction with their micro-environment. Typical topics under investigation are the study of cell growth, cell migration or stem cell differentiation. Here, the tailoring is achieved by on one hand a wide range of processable materials and on the

other hand a resolution and feature sizes which, in combination, allow to mimic in vivo physiological environments. Accessible patterning scales cover sub-micrometer features as well as sample volumes of up to several 10 mm³ or lateral areas in the cm² range. Samples can be produced from biocompatible, cell binding/repelling, hydrophobic and hydrophilic polymers with different mechanical characteristics as well as hydrogels.

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Recent Publications

  • Near-Infrared Light-Sensitive Polyvinyl Alcohol Hydrogel Photoresist for Spatiotemporal Control of Cell-Instructive 3D Microenvironments
    Qin, X.-H., Wang, X., Rottmar, M., Nelson, B. J., Maniura-Weber, K., Adv. Mater. 2018, DOI: 10.1002/adma.201705564
  • A 3D Real-Scale, Biomimetic, and Biohybrid Model of the Blood-Brain Barrier Fabricated through Two-Photon Lithography
    Marino, A., Tricinci, O., Battaglini, M., Filippeschi, C., Mattoli, V., Sinibaldi, E., Ciofani, G., Small 2017, DOI: 10.1002/smll.201702959
  • Two-photon polymerization for production of human iPSC-derived retinal cell grafts
    Worthington, K. S., Wiley, L. A., Kaalberg E. E., Collins, M. M., Mullins, R. F., Stone, E. M., Tucker, B. A., Acta Biomaterialia, 2017, DOI: 10.1016/j.actbio.2017.03.039
  • Guiding Cell Attachment in 3D Microscaffolds Selectively Functionalized with Two Distinct Adhesion Proteins
    Richter, B., Hahn, V., Bertels, S., Claus, T. K., Wegener, M., Delaittre, G., Barner-Kowollik, C., Bastmeyer, M., Adv. Mater. 2017, 29, DOI: 10.1002/adma.201604342
  • Three-dimensional cage-like microscaffolds for cell invasion studies
    Spagnolo, B., Brunetti, V., Leménager, G., De Luca, E., Sileo, L., Pellegrino, T., Pompa, P.P., De Vittorio, M., Pisanello F., Scientific Reports 5, DOI: 10.1038/srep10531
  • The Osteoprint: a Bio-Inspired Two-Photon Polymerized 3D Structure for the Enhancement of Bone-Like Cell Differentiation
    A.Marino, C. Filippeschi, G.G. Genchi, V. Mattoli, B. Mazzolai, and G. Ciofani, Acta Biomaterialia 2014, DOI: 10.1016/j.actbio.2014.05.032
  • Multifunctional polymer scaffolds with adjustable pore size and chemoattractant gradients for studying cell matrix invasion
    A.M. Greiner, M. Jäckel, A.C. Scheiwe, D.R. Stamow, T.J. Autenrieth, J. Lahann, C.M. Franz, and M. Bastmeyer, Biomaterials 2014 Jan; 35(2):611-9.doi: 10.1016/j.biomaterials.2013.09.095
  • Fabrication and Characterization of Magnetic Microrobots for Three-Dimensional Cell Culture and Targeted Transportation
    S. Kim, F. Qiu, S. Kim, A. Ghanbari, C. Moon, L. Zhang, B.J. Nelson, and H. Choi, Advanced Materials DOI: 10.1002/adma.201301484